The HLA peptidome

Our lab’s main research interest focuses on molecular immunology, with a special interest HLA-peptidomics; the research field aimed at characterization of the full repertoires of HLA peptides presented by human cells (HLA peptidome) and the implementation of the HLA peptidomics into development of personalized cancer immunotherapy. Another direction for the HLA peptidomics studies is aimed at defining its components, which may elicit the undesired immune response during autoimmunity and inflammatory diseases. These research directions rely heavily on the use of the modern tools of peptidomics and proteomics, especially mass spectrometry and bioinformatics. Therefore, much of the research efforts are directed at advancing these important technologies and methodologies and promoting their use in these fields.